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专利名称：Compositions and methods for the
preparation of protease resistant humangrowth hormone glycosylation mutants
发明人：Defrees, Shawn申请号：EP11173427.3申请日：20060410公开号：EP2386571B1公开日：20160601
摘要：The present invention relates to protease resistant mutants of human growthhormone, which contain newly introduced proteolysis resistant mutations and N-linked orO- linked glycosylation site(s), such that these recombinantly produced polypeptideshave glycosylation patterns distinctly different from that of the naturally occurringhuman growth hormone. The polynucleotide coding sequences for the mutants,
expression cassettes comprising the coding sequences, cells expressing the mutants, andmethods for producing the mutants are also disclosed. Further disclosed are
pharmaceutical compositions comprising the mutants and method for using the mutants.
申请人：RATIOPHARM GMBH
地址：DE
国籍：DE
代理机构：Neuefeind, Regina
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