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专利名称：Quinoline derivatives as antibacterial agents发明人：Koenraad Jozef Lodewijk Marcel Andries,Anil
Koul,Jerome Emile Georges
Guillemont,Elisabeth Therese JeannePasquier
申请号：US11296918申请日：20051208
公开号：US20060281741A1公开日：20061214
摘要： The present invention relates to the use of a compound for the manufacture ofa medicament for the treatment of a bacterial infection, said compound being a
compound of formula a pharmaceutically acceptable acid or base addition salt thereof, astereochemically isomeric form thereof or a N-oxide form thereof, wherein Ris hydrogen,halo, polyhaloCalkyl, Calkyl, Ar or Het; p is an integer equal to 1 or 2; Ris Calkyloxy,CalkyloxyCalkyloxy or Calkylthio; Ris Ar, Het or Het; Rand Reach independently arehydrogen, Calkyl or benzyl; or Rand Rtogether and including the N to which they areattached may form a radical selected from the group of pyrrolidinyl, 2-pyrrolinyl, 3-pyrrolinyl, pyrrolyl, imidazolidinyl, pyrazolidinyl, 2-imidazolinyl, 2-pyrazolinyl, imidazolyl,pyrazolyl, triazolyl, piperidinyl, pyridinyl, piperazinyl, pyridazinyl, pyrimidinyl, pyrazinyl,triazinyl, morpholinyl and thiomorpholinyl, each of said rings may optionally besubstituted with Calkyl, halo, polyhaloCalkyl, hydroxy, hydroxyCalkyl, Calkyloxy, amino,mono- or di(Calkyl)amino, Calkylthio, CalkyloxyCalkyl, CalkylthioCalkyl or pyrimidinyl; Rishydrogen, halo, polyhaloCalkyl, Calkyl, Calkyloxy, Calkylthio; or two vicinal Rradicals may
be taken together to form a bivalent radical of formula —CH═CH—CH═CH—; r is aninteger equal to 1 or 2; Ris hydrogen, Calkyl, Ar, Het or Het; provided that the bacterialinfection is other than a Mycobacterial infection.
申请人：Koenraad Jozef Lodewijk Marcel Andries,Anil Koul,Jerome Emile GeorgesGuillemont,Elisabeth Therese Jeanne Pasquier
地址：Beerse BE,Berchem BE,Ande FR,Le Neubourg FR
国籍：BE,BE,FR,FR
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